Which of the following symptoms is commonly associated with sickle cell disease?

High fatigue is commonly associated with sickle cell disease due to the body's reduced ability to transport oxygen effectively. In this condition, the abnormal shape of red blood cells leads to blockages in blood vessels, resulting in decreased blood flow and oxygen delivery to tissues. This can cause symptoms like pain episodes (known as vaso-occlusive crises) and severe fatigue, as the body struggles to maintain energy levels and perform normal physiological functions. Chronic anemia, often seen in patients with sickle cell disease, also contributes to feelings of fatigue, as there are insufficient red blood cells available to carry adequate oxygen to meet the body's demands. Therefore, recognizing high fatigue as a primary symptom helps in understanding the overall impact of sickle cell disease on individuals' daily lives.