When presented with a red and white mixed lesion, which portion should be biopsied?

When evaluating a mixed lesion consisting of both red and white components, the most prudent approach is to biopsy the entire lesion, encompassing both the red and white portions. This method ensures a comprehensive sampling of the tissue, allowing for an accurate diagnosis.

The red areas often indicate inflammation or active disease processes, while the white portions can be indicative of keratinization or dysplastic changes. By including both areas in the biopsy, the pathologist can better discern the relationship between the different characteristics of the lesion and determine any underlying conditions, such as premalignant changes or other significant pathology.

Biopsying only one portion might miss critical diagnostic information, as certain diseases may exhibit unique features in both red and white areas. Thus, targeting the mixed nature of the lesion as a whole is crucial for obtaining the most relevant pathological insights.