What pain reliever is most appropriate for a patient with kidney disease?

Acetaminophen is the most appropriate pain reliever for a patient with kidney disease because it is generally considered safe for use in individuals with compromised renal function. Unlike nonsteroidal anti-inflammatory drugs (NSAIDs) such as naproxen or aspirin, acetaminophen does not have significant nephrotoxic effects or cause issues with renal perfusion.

Patients with kidney disease may be at risk for complications from NSAIDs due to their effects on renal blood flow and potential to exacerbate fluid retention and hypertension. Morphine, while an effective pain reliever, can lead to accumulation and increased risk of side effects if kidney function is severely impaired since it is also primarily metabolized by the kidneys.

Therefore, acetaminophen is often recommended as the first line for managing pain in patients with kidney disease, as it provides effective analgesia while minimizing risks associated with kidney function.