In what situation should aspirin be avoided as a pain reliever?

Aspirin can sometimes be avoided in patients with kidney disease due to its potential effects on renal function. Nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin, can lead to reduced blood flow to the kidneys and can potentially cause or exacerbate kidney damage in susceptible individuals. This is particularly important in patients who already have compromised kidney function, as their ability to handle medications can be significantly impaired.

In contrast, while aspirin does have specific uses for dental pain and can be beneficial in patients with a history of heart disease or to manage specific symptoms, caution is typically advised when it comes to patients with kidney disease. Additionally, while the use of aspirin is commonly discouraged in children under 18 years old due to the risk of Reye's syndrome, this doesn't directly pertain to kidney issues. Therefore, kidney disease presents a significant reason to avoid aspirin for pain relief.