High fatigue is a symptom found in which of the following conditions?

High fatigue is commonly associated with sickle cell disease due to the chronic nature of the condition. In sickle cell disease, the abnormal hemoglobin leads to the production of sickle-shaped red blood cells that can obstruct blood flow and cause pain, as well as leading to hemolytic anemia, which significantly reduces the oxygen-carrying capability of the blood. This results in fatigue as the body struggles to deliver sufficient oxygen to tissues and organs, compounded by episodes of pain crisis and the body’s continual effort to replenish red blood cells.

While other conditions listed may have fatigue as a secondary symptom, sickle cell disease is more directly linked due to the physiological mechanisms involved, primarily related to anemia and oxygen transport deficiency. Osteoporosis, hypertension, and appendicitis can all contribute to feelings of fatigue but not to the same degree or with the same underlying causes as seen in sickle cell disease.